https://www.selleckchem.com/products/Cyclopamine.html The DESIREE project has developed a platform offering several complementary therapeutic decision support modules to improve the quality of care for breast cancer patients. All modules are operating consistently with a common breast cancer knowledge model (BCKM) following the generic entity-attribute-value model. The BCKM is formalized as an ontology including both the data model to represent clinical patient information and the termino-ontological model to represent the application domain concepts. This ontological model is used to describe data semantics and to allow for reasoning at different levels of abstraction. We present the guideline-based decision support module (GL-DSS). Three breast cancer clinical practice guidelines have been formalized as decision rules including evidence levels, conformance levels, and two types of dependency, "refinement" and "complement", used to build complete care plans from the reconciliation of atomic recommendations. The system has been assessed on 138 decisions previously made without the system and re-played with the system after a washout period on simulated tumor boards (TBs) in three pilot sites. When TB clinicians changed their decision after using the GL-DSS, it was for a better decision than the decision made without the system in 75 % of the cases.Continuous blood pressure (BP) measurement is crucial for reliable and timely hypertension detection. State-of-the-art continuous BP measurement methods based on pulse transit time or multiple parameters require simultaneous electrocardiogram (ECG) and photoplethysmogram (PPG) signals. Compared with PPG signals, ECG signals are easy to collect using wearable devices. This study examined a novel continuous BP estimation approach using one-channel ECG signals for unobtrusive BP monitoring. A BP model is developed based on the fusion of a residual network and long short-term memory to obtain the spatial-temporal information o