https://www.selleckchem.com/products/YM155.html FABR reveals as a promising alternative for simultaneous removal of nitrogen and COD from low COD/N ratio wastewaters.This study aimed to develop an aptasensor for paraquat detection by gold nanoparticles. The specific aptamer for paraquat was selected by using the SELEX process via capillary electrophoresis. Sixty-three aptamer candidates were amplified by asymmetric PCR and screened for paraquat binding using gold nanoparticles (AuNPs). Aggregation of AuNPs was specifically induced by desorption of paraquat binding aptamers from the surface of AuNPs as a result of aptamer-target interaction leading to the color change from red to purple. Aptamer 77F with the following sequence 5'-AGGCTTACACCTGAAAAGCGGCTTAATTTACACTACTGTAT-3' was selected as a highly specific aptamer for paraquat. The detection limit of paraquat was 0.267 µg/mL by colorimetry and 1.573 µg/mL by the quartz crystal microbalance (QCM) technique. This aptamer showed specificity for paraquat by colorimetry. Dimethyl phophite, diethyl phophite and O,O diethyl thiophosphate potassium salt did not react by colorimetry but, exhibited a weak nonspecific reaction by QCM. This is first time that an aptasensor was used for detection of paraquat based on QCM. However, the aptasensor based on the colorimetric method simply uses a generation of a signal that can be detected by the naked eye. This technique is rapid, low cost easy to use and suitable for on-site detection of herbicide residue.This study aimed to assess the global mapping risk of human islet isolation, using a failure mode and effect analysis (FMEA), and highlight the impact of quality assurance procedures on the risk level of criticality. Risks were scored using the risk priority number (RPN) scoring method. The risk level of criticality was made based on RPN and led to risk classification (low to critical). A raw risk analysis and a risk control analysis (with control means and quality assurance perfo