https://www.selleckchem.com/products/cpi-203.html To investigate the optimal dose of dexmedetomidine to maintain hemodynamic stability, prevent of cough and minimize postoperative pain for patients undergoing laparoscopic cholecystectomy. One hundred twenty patients were randomly divided into D , D , D and NS groups, and dexmedetomidine 0.4, 0.6, 0.8μg/kg and normal saline were administrated respectively. Patients' heart rate, systolic blood pressure and diastolic blood pressure were measured at T -T . The incidence of cough was recorded. Other parameters were noted, the time of spontaneous respiratory recovery and extubation, visual analogue scale scores and dosage of tramadol. The heart rate, systolic blood pressure and diastolic blood pressure of D and D groups has smaller fluctuations at T2-3 and T7 compared with NS and D groups (P < 0.05). The incidence of cough was lower in D and D groups than NS group (P < 0.05). The visual analogue scale scores and tramadol dosage of D and D groups were lower than NS group (P < 0.05). The time of spontaneous respiratory recovery and extubation in D group was longer than that in D and D groups (P < 0.05). Intravenous infusion of 0.6μg/kg dexmedetomidine before induction can maintain hemodynamic stability, decrease cough during emergence, relieve postoperative pain of patients undergoing laparoscopic cholecystectomy. ChiCTR1900024801 , registered at the Chinese Clinical Trial Registry, principal investigator Qin Ye, date of registration July 28, 2019. ChiCTR1900024801 , registered at the Chinese Clinical Trial Registry, principal investigator Qin Ye, date of registration July 28, 2019. There are distinct differences in the implementation of physiotherapeutic care in nursing homes. Both nationally and internationally staffing levels of physiotherapy differ significantly between and within nursing homes. Since legislation or guidelines that specify the parameters of physiotherapy required in nursing homes are lacking, it is unkn