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Guest 142 21st Jan, 2025

https://www.selleckchem.com/products/fin56.html Solanum nigrum Linne polysaccharide (SNLP), an active ingredient from Solanum nigrum Linne, has been proposed to inhibit tumor growth and display immunomodulatory activity. However, the molecular mechanism related to immune regulation remains unclear. In the present study, a homogeneous polysaccharide (SNLP-1) was extracted, the immune effects and the underlying molecular mechanisms were investigated. The immunomodulatory activity assay in vitro showed that SNLP-1 promoted the release of NO and TNF-α and IL-6 secretion in macrophages. In tumor-bearing mice, SNLP-1 could improve immune function including increasing the spleen index, thymus index and inducing Th1 responses mediated by IL-2, IFN-γ, and TNF, as well as decreasing the tumor weight. Furthermore, SNLP-1 elevated the expression of the critical nodes in the TLR4-Myd88 signaling pathways in vitro and in vivo. These results indicated that TLR4-MyD88 signal pathway may be one of the signal pathways of immune regulation of SNLP-1. The gut microbiome can mediate the efficacy of immune checkpoint inhibitors (ICI). Meanwhile, proton pump inhibitors (PPI) can modulate the gut microbiome significantly. However, the impact of PPI use on the clinical outcome of ICI therapy remains unclear. Searches of PubMed, EMBASE, and the Cochrane Library were conducted to retrieve studies exploring the relationship between PPI use and the clinical benefit of patients undergoing ICI therapy through June 2020. The pooled hazard ratio (HR) and 95% confidence intervals (CIs) were calculated to evaluate the influence of PPI use on overall survival (OS) and progression-free survival (PFS). A total of seven studies were eligible for our final analysis. There was no significant association between PPI use and OS or PFS (PPI users versus non-users HR for OS 1.05, 95% CI 0.79-1.40, P=0.73; HR for PFS 0.90, 95% CI 0.66-1.23, P=0.51). However, subgroup analyses demonstrated that PPI use was relat
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