https://www.selleckchem.com/products/cc-92480.html Besides being used as a facile enrichment tool, a combination of CpOGAD298N with the proximity ligation assay (PLA) is successfully used to quantify O-GlcNAc modified histone H2B, which is as low as femtomoles in MCF-7 cell lysate. These results suggest that CpOGAD298N is a specific tool for detection (far-western, flow cytometry analysis, and confocal imaging) and enrichment of O-GlcNAcylated proteins and peptides, and the CpOGAD298N-PLA method is useful for quantifying certain O-GlcNAc protein.Rational utilization of diverse weak forces in directing multiple-constituent chiral coassemblies is of vital importance in fabricating functional chiroptical materials. In this work, arene-perfluoroarene (AP) and hydrogen bonds were orthogonally employed to afford synergistic binary and ternary coassemblies. On the supramolecular scale, amino acids were connected to achiral pyrene moieties, which packed into supramolecular tilt chirality individually. The modified aromatic amino acids coassembled with melamine and octafluoronaphthalene (OFN) through multiple hydrogen bond and AP interactions, respectively, to construct binary and ternary systems. The introduction of hydrogen bonds and AP interactions shall alter the nanostructures and luminescent properties. Emergence of macroscopic chirality at nanoscale was realized, accompanied by the inversion of circularly polarized luminescence. These interactions working in an orthogonal way regulated the supramolecular chirality, emission properties, nanostructure transformation, and chiroptical activities, which enriched the protocols in designing functional chiral composites.Cancer metastasis is still a major obstacle in clinical cancer therapy and a paramount cause of cancer deaths. Designing multifunctional nanoplatforms with an enhanced diagnostic sensitivity and anti-metastasis efficiency against tumors represents a major trend in current cancer management. Herein, we report t