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https://www.selleckchem.com/products/gdc-0068.html Nicotine 0.5mg/kg and CSE 0.5mg/kg significantly induced reward effects (p<0.05). There was no decrease of reward effect during the extinction-reinstatement stage of the postconditioning phase (p>0.05), while quercetin 50mg/kg both induced along with nicotine or CSE was able to inhibit the reward effect of nicotine (p>0.05). Quercetin reduced the risk of nicotine dependence and has a potential effect to use as a therapy for nicotine dependence, especially as a preventive agent. Quercetin reduced the risk of nicotine dependence and has a potential effect to use as a therapy for nicotine dependence, especially as a preventive agent. The main therapy of β-thalassemia major are blood transfusion and iron chelation drugs. However, those therapies also have some adverse effects and problems such as iron overload, transfusion reactions, nutritional deficiencies, and patient compliance problems. Those arising problems also have an impact on therapy cost. Hence, this study was designed to analyze drug utilization study and cost of therapy in β-thalassemia major adult patients at Dr. Soetomo General Hospital Surabaya. This research was conducted in descriptive observational-retrospective design using secondary data obtained from patient's medical records and billing registrations from January 1-December 31, 2019. There were 18 patients out of 233 patients that were analyzed. Deferasirox was the most administered drug with doses between 500mg/day-1,500mg/day while deferiprone was ranged between 1,500 and 4,500mg/day. Patients also received transfusion reaction drugs with dexamethasone injection 5mg/ml which was administered the most. The most administered supplement was folic acid 1mg. Patients had an increase in serum ferritin due to low compliance. Deferasirox had the most adherence number of patients with decrease of serum ferritin. The two highest costs of direct medical components were top-up medicines and consumable medi

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