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https://www.selleckchem.com/products/brivudine.html At presentation, isolated metastasis from oropharyngeal squamous cell carcinoma is rare. Liver is a relatively uncommon first site of failure, especially in the absence of other distant metastases, particularly without diagnosis of lung metastases. We report on a case of HPV-related oropharyngeal squamous cell carcinoma with synchronous liver metastasis treated with radiation therapy. This condition, defined as "oligometastatic state," describes a subset of patients with limited volume metastatic disease in whom favorable outcomes were reported with the use of local ablative therapies on both the primary tumor and metastatic sites. As a definitive treatment, we offered the patient, ineligible for other therapeutic approaches, exclusive radiation treatment on the head and neck region and a stereotactic ablative approach targeted to the liver metastasis. © 2020 The Authors. Published by the British Institute of Radiology.Aberrant course of internal carotid arteries (ICA) is rarely seen. In patients who are asymptomatic, anomalies may be detected incidentally during head and neck examination. Symptomatic patients may present with hearing loss, pulsatile tinnitus, dysphagia or a foreign body sensation in the posterior pharynx. If the retropharyngeal course of ICA remains undiagnosed, accidental biopsy or surgical intervention can result in life threatening complications. The abnormal course of ICA results from a complex defect in embryological development and is unlikely to be an acquired process. Previously, bilateral and unilateral agenesis, hypoplastic, retropharyngeal tortuous ICA and kissing sellar ICA have been described in literature. We used various imaging techniques to describe this first case of fused ICA with an aberrant course through the clivus and dorsum sellae. The patient also presented with patulous Eustachian tubes on both the left and right side. © 2020 The Authors. Published by the British Institut

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