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https://www.selleckchem.com/mTOR.html This meta-analysis investigated the link between lying and theory-of-mind (ToM) by integrating findings from 81 studies involving 7,826 children between 2 and 14 years of age from 14 different collectivist and individualist cultures. Overall, there was a small, significant positive association (r = .23). Four main moderators were examined facet of lying (understanding, instigated production, spontaneous production, maintenance); valence of lies (antisocial, prosocial); type of ToM (first-order, second-order); and culture (collectivist, individualist). Facet of lying and type of ToM were significant moderators. ToM was positively related to all facets of lying, but most strongly linked to lie maintenance and weakest for spontaneous production. Both first-order and second-order ToM were positively related to lying, but the link was stronger for the former.Hypertension is a multifaceted condition influenced by genetic and environmental factors and estimated to cause 9.4 million deaths globally every year. Recently, there has been growing interest in understanding the gut microbe-host interaction in the maintenance of health or disease states, but relatively few studies have shown an association between the gut microbiome and specific types of hypertension. The deoxycorticosterone acetate (DOCA)-salt model of hypertension in rats is known to have a neurogenic component linked to increased sympathetic nervous system activity. As such, our lab has recently shown the hypertensive response in DOCA treated rats requires an intact organum vasculosum of the lamina terminalis (OVLT), a central hypothalamic circumventricular organ. Currently, we hypothesize the OVLT mediates changes in the gut microbiome associated with concomitant hypertension. Herein, we report that the hypertensive effects of DOCA-salt treatment were significantly attenuated throughout the 24-hour day/night cycle in OLVT lesioned rats on days 1, 3, and 9-21 of DOCA treatm
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