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https://www.selleckchem.com/products/dc661.html 86) which were similar to previously described TBRmean and TBRmax methods. AMA analysis was much quicker to perform than standard TBR assessment (3.4min versus 15.1min, P<0.0001). AMA was correlated with Framingham stroke risk scores and Framingham risk score for hard cononary heart disease. AMA is a simple, rapid and reproducible method of quantifying global F-NaF uptake across the ascending aorta and aortic arch that correlates with cardiovascular risk scores. AMA is a simple, rapid and reproducible method of quantifying global 18F-NaF uptake across the ascending aorta and aortic arch that correlates with cardiovascular risk scores. The presence of myocardial scar in CS patients results in poor prognosis and worse outcomes. F-fluorodeoxyglucose ( F-FDG) PET/CT excels at visualizing inflammation but is suboptimal at detecting scar. We evaluated PET/CT sensitivity to detect scar and investigated the incremental diagnostic value of automated PET-derived data. 176 patients who underwent cardiac magnetic resonance (CMR) and N-13 ammonia/ F-FDG cardiac PET/CT for suspected CS within 3months were enrolled. Scar was defined as late gadolinium enhancement (LGE) on CMR without concordant F-FDG uptake on F-FDG PET/CT. Accuracy of cardiac PET/CT at detecting scar (perfusion defect without concordant F-FDG uptake) was assessed before and after addition of automated PET-derived data. Sensitivity of PET/CT for scar detection was 45.3% (specificity 88.9%). Addition of PET-derived LV volumes and function in a logistic regression model improved sensitivity to 57.0% (specificity 80.0%, AUC 0.72). Addition of phase analysis maximum segmental onset of myocardial contraction > 61 improved AUC to 0.75, correctly relabeling 16.3% of patients as scar (net reclassification index 8.2%). Sensitivity of gated PET MPI alone for scar detection in CS is suboptimal. Adding PET-derived volumes/function and phase analysis data results in improved dete
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