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https://www.selleckchem.com/products/oicr-9429.html 001) which can be attributed to the significant decrease in apoptotic cells (P<0.05) as evidenced by cell cycle analysis. Preconditioning of Piper longum L. (10-100μg/mL) enhanced Ca accumulation and matrix mineralization as observed by Von Kossa and Alizarin Red staining where ALP activity was elevated 3.6 folds as compared to untreated WJMSCs (P<0.001). RT-PCR analysis exhibited up regulation of Runx2, Osterix, ALP and OPN mRNAs. We demonstrate for the first time that Piper longum L. fruit extract enhanced osteogenic differentiation of WJMSCs. This finding can be clinically translated into development of an anti-osteoporotic agent. We demonstrate for the first time that Piper longum L. fruit extract enhanced osteogenic differentiation of WJMSCs. This finding can be clinically translated into development of an anti-osteoporotic agent. Stem bark of Anogeissus latifolia Roxb. (Family Combretaceae) is used traditionally and ethnomedicinally for correction of kidney disorders. The present study demonstrates the nephroprotective potential of stem bark of A. latifolia Roxb. The HPTLC fingerprint and HPLC analysis were carried out to standardize the ethanolic extract of stem bark of A. latifolia (ALEE) using ellagic acid as a marker. Nephrotoxicity was induced in adult Wistar albino rats by gentamicin (100mg/kg, intraperitoneally for 8 days) and they were treated with ALEE (100, 200 and 400mg/kg, orally for 8 days), ellagic acid (10mg/kg, orally for 8 days) and cystone syrup (5ml/kg, orally), a standard reference a polyherbal formulation. Urine volume, serum and urine levels of creatinine, urea and uric acid, oxidative stress parameters (lipid peroxidation, catalase, superoxide dismutase and reduced glutathione), inflammatory markers (TNF-α and IL-6) and kidney weight along with its histological changes were studied in experimental animals. HPTLC, HPLC and LC-MS analysis of ALEE revealed the presence of ellagic acid and

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