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https://www.selleckchem.com/products/lw-6.html One group was subjected to 11 scans between weeks 20 and 40 of age, whereas the other groups were subjected to 5 scans between weeks 26-34, 32-40 and 40-46, respectively. The long-term monitoring approach showed small but significant changes in the static bone morphometric parameters compared to the other groups. However, no interaction effect between groups and genotype was found, suggesting that PolgA mutation does not render bone more or less susceptible to long-term micro-CT imaging. The differences between groups observed in the static morphometric parameters were less pronounced in the dynamic morphometric parameters. Moreover, the body weight and FI were not affected by more frequent imaging sessions. Finally, we observed that longitudinal designs including baseline measurements at young adult age are more powerful at detecting effects of in vivo micro-CT imaging on hallmarks of aging than cross-sectional comparisons between multiple groups of aged mice subjected to fewer imaging sessions.The current study determined the area-per-player during small- or large-sided games with or without goalkeeper that replicates the relative (m·min-1) total distance, high-intensity running distance, sprint distance and metabolic power covered during official matches. Time-motion analysis was performed on twenty-five elite soccer-players during 26 home-matches. A total of 2565 individual samples for SSGs using different pitch sizes and different number of players were collected and classified as SSGs with (SSG-G) or without goalkeeper (SSG-P). A between-position comparison was also performed. The area-per-player needed to replicate the official match demands was largely higher in SSG-G vs SSG-P for total distance [187±53 vs 115±35 m2, effect size (ES) 1.60 95%CI 0.94/2.21], high-intensity running distance [262±72 vs 166±39 m2, ES 1.66(0.99/2.27)] and metabolic power [177±42 vs 94±40, ES 1.99(1.31/2.67)], but similar for sprint di

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