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https://www.selleckchem.com/products/ehop-016.html n.Kv1.3 potassium channel is considered as a target for the treatment of autoimmune diseases such as multiple sclerosis (MS), since Kv1.3 blockade suppresses memory T cell activation including cytotoxic CD8+ T cells. However, the underlying signaling pathway related to autoimmune CD8+ T cell inhibition by Kv1.3 channel in neuroinflammatory diseases remains unclear. We found that ImK, a selective Kv1.3 blocker, reduced auto-reactive CD8+ T cell infiltration in the spinal cords of experimental autoimmune encephalomyelitis (EAE) rats, an animal model of MS. ImK suppressed transcriptional factor Blimp-1 expression and reduced the cytotoxicity of CD8+ T cells on neuronal cells. Furthermore, ImK upregulated co-inhibitory molecule PD-1 to inhibit B lymphocyte-induced maturation protein (Blimp-1) in an IL-2 independent way. In addition, PD-1 inhibitor impaired the suppression of ImK on CD8+ T cells and accelerated EAE progression. Our study demonstrated a novel regulatory mechanism of Kv1.3 blockade on modulating CD8+ T cell differentiation through PD-1/Blimp-1 signaling. This work expands the understanding of Kv1.3 channel for modulating neuroinflammation.Since the outbreak of the COVID-19 pandemic in South Korea in January 2020, many South Korean employees have been experiencing work stressors, threats of job insecurity, and feelings of isolation, which together lead to emotional exhaustion. The present study aimed to compare the emotional exhaustion of South Korean employees before and after the pandemic, as well as to examine how the demographic characteristics of employees affected their emotional exhaustion. We administered surveys to 276 employees before the COVID-19 pandemic (from July to October 2019) and 301 employees after its onset (from March to April 2020). A series of t-tests demonstrated that both employee samples were similar demographically. Hierarchical regression analyses revealed that even when controll

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