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https://www.selleckchem.com/products/q-vd-oph.html Hence, the interaction of methylene blue (MB) with the duplex section of SHPs was impeded, which brought about a decreased electrochemical signal. Benefiting from the cyclic amplification of the TSDR and the higher cleavage activity of three-leg DNAzyme walkers, the proposed sensing strategy showed remarkable improvement in sensitivity with a low detection limit of 0.27 fM for miR-155. Owing to the precise design of the THP, this method exhibited excellent specificity to distinguish miR-155 from the single-base and triplex-base mismatched sequences. This sensing strategy importing the flexible THP can be utilized to detect various nucleic acid biomarkers by only redesigning the THP without changing the main circuit or reporter constructs, showing the great versatility and potential for the early diagnostics and biological analysis.Electrocatalytic two-electron (2e-) oxygen reduction reaction (ORR) has been regarded as an efficient strategy to achieve onsite H2O2 generation under ambient conditions. However, due to the sluggish kinetics and competitive reaction between 2e- and 4e- ORR, exploring more efficient ORR catalysts with dominant 2e- ORR selectivity is of significance. Herein, hollow N-doped carbon spheres (HNCS) with abundant micropores through a template-directed method are presented. Consequently, the selectivity of the HNCS reaches ∼91.9% at 0.7 V (vs RHE), and the output for H2O2 production is up to 618.5 mmol gcatalyst-1 h-1 in 0.1 M KOH solution. The enhanced performance of HNCS for H2O2 electrosynthesis could be attributed to the hollow structure and heteroatom/defect/pore incorporation. The strategy presented here could shed light on the design of efficient carbon-based materials for improved 2e- ORR.Superwetting membranes based on steric exclusion and affinity difference have drawn substantial interest for oil/water separation. However, the state-of-the-art membranes fail to literally sort out fouli

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