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https://www.selleckchem.com/products/z-lehd-fmk-s7313.html The interface supersaturates because the drug-molecule release rate from the fast-eroding HPMC fibers is greater than the precipitation rate within; the solubility increases proportionally to the concentration of micelle-forming POS. Similarly, the dissolution fluid supersaturates, and due to the presence of POS in the solution the terminal solubility is increased. Thus the solid-solution fibers with dual, low-molecular-weight HPMC-POS excipient enhance the release rate, supersaturation, and solubility of sparingly-soluble drugs, and their delivery rate into the blood stream. V.The application of hollow nerve conduits in the repair of peripheral nerve defects is effected by inferior recovery, and nerve extension is hampered by the scar tissue generated during the repair process. In this study, the filler in hollow nerve conduit, chitosan/oxidized hydroxyethyl cellulose (CS/OHEC) hydrogel loaded asiaticoside liposome and the conductive reduced graphene oxide (rGO) were developed and used to reform the microenvironment for peripheral nerve regeneration. The physiochemical properties of CS/OHEC/rGO/asiaticoside liposome hydrogel were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and compressive modulus, porosity, swelling ratio, degradation and conductivity. In addition, the asiaticoside release profiles in vitro were investigated. The hydrogel had a continuous porous network structure with pore size distribution in the range of 50-250 μm. The majority of the hydrogels had porosities above 70%, and a compressive modulus of 0.45 MPa. The weight loss rate of hydrogel reached 76.14 ± 4.45% within 8 weeks. The conductivity of the hydrogel was 5.27 ± 0.42 × 10-4 S/cm. The hydrogel was non-toxic and suitable for adhesion and proliferation of nerve cells in vitro. In addition, the application of electrical stimulation after the addition of rGO can promote the diff

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