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https://www.selleckchem.com/products/ms-275.html Understanding the driving forces behind built-up land expansion is crucial in urban planning and management. Using the Pearl River Delta urban agglomeration as research area, four landscape metrics were used to analyze landscape characteristics of urban expansion from 1990 to 2015. Spatial autocorrelation analysis was used to study the characteristics of built-up land expansion, while geographical detector was employed to identify the driving forces of urban land growth and their interactions. The results show the extent of built-up land has been increasing, the structure has become more complex, the level of fragmentation has been increasing, and the aggregation degree is in decline. The built-up landscape index shows spatial heterogeneity occurring in the core and peripheral towns of cities, as well as in the core and peripheral areas of the entire region. Also, changes in the built-up landscape index indicate increased spatial aggregation occurring in the past 25 years. Results from the geographical detector show natural, socio-economic, and transportation-related factors have substantial influence on built-up land expansion. Elevation, slope, population density, change in population density, and road network density were shown to have high influencing power. The influencing powers of slope and change in population density were also found to be different from other factors, highlighting their important role in urban development. Also, there were two types of interactions found, enhance nonlinear and enhance bivariate interactions, indicating the compounding influence of interactions between significant determinants. This study provides a new perspective and methodological approach in evaluating the driving forces behind built-up land expansion and their interactions.The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arres

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