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https://www.selleckchem.com/products/fingolimod.html Future Directions NPWT has been used in 2-months up to 18-years old children with deep 2nd to 3th degree burn of multiple etiologies, from a few days up to several months, on small to 40% TBSA surfaces, and in difficult areas. Data gathered provides empirical guidelines on NPWT use in pediatrics burns using continuous mode with a pressure of -50 to -75 mmHg for children younger than 2 years, and -75 to -125 mmHg in children over 2-years of age. Prospective randomized studies are needed to provide validated rules.Significance In biomedical setup, at large, and drug delivery, in particular, transdermal patches, hypodermal needles and/or dermatological creams with the topical appliance are among the most widely practiced routes for transdermal drug delivery. Owing to the stratum corneum layer of the skin, traditional drug delivery methods are inefficient, and the effect of the administered therapeutic cues is limited. Recent Advances The current advancement at the micro- and nano- level has revolutionized the drug delivery sector. Particularly, various types of microneedles are becoming popular for drug delivery applications because of safety, patient compliance, and smart action. Critical Issues Herein, we reviewed state-of-the-art microneedles as a smart and sophisticated drug delivery approach. Following a brief introduction, the drug delivery mechanism of microneedles is discussed. Different types of microneedles, i.e., solid, hollow, coated, dissolving, and hydrogel-forming microneedles, are discussed with suitable examples. The latter half of the work is focused on the applied perspective and clinical translation of microneedles. Furthermore, a detailed overview of clinical applications and future perspectives are also included in this review. Future Directions Regardless of ongoing technological and clinical advancement, the focus should be diverted to enhance the efficacy and strength of microneedles. Besides

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