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https://www.selleckchem.com/products/pt2385.html RESULTS We obtained five rabbit mAbs against LAM, four of which had high sensitivities (100 pg/ml) and affinities (1.16-1.73 × 10-9 M) toward LAM. They reacted with M.tb H37Rv, M. bovis, and slow-growing NTM, but not with rapid-growing NTM. Similar results were obtained with mycobacterium isolates, where 96% of the Mtb isolates and 90% of the M. avium-intracellulare isolates were successfully identified. CONCLUSION The novel rabbit LAM-specific mAbs performed well at recognizing LAM from slow-growing pathogenic mycobacteria, which support their future clinical application. V.BACKGROUND The humoral immune response is pivotal to protect the host from Salmonella typhimurium (S. typhimurium) infection. Previously, we found that core fucosylation catalyzed by core fucosyltransferase (Fut8) could regulate the immune responses. However, the role of core fucosylation during S. typhimurium infection remains unclear. METHODS To demonstrate the role of Fut8 in S. typhimurium infection, we infected Fut8+/+ and Fut8-/- mice using S. typhimurium. The production of antiserum against the S. typhimurium was detected. The expression of T and B cell activation-related genes during S. typhimurium infection was analyzed. The role of core fucosylation on CD4+ T-B cell interaction and B cell generation was investigated during S. typhimurium infection. The production of sIgA was compared between Fut8+/+ and Fut8-/- mice. RESULTS Compared to Fut8+/+ mice, the number of S. typhimurium colonized in the cecum was markedly increased in Fut8-/- mice. The production of the IgG and sIgA specific for S. typhimurium was significantly decreased in Fut8-/- mice. Moreover, loss of Fut8 decreased the induction of Th2-type cytokines from splenic cells of Fut8-/- mice during S. typhimurium infection. In addition, we found that the core fucosylation regulated the interaction between B and T cells in the lipid raft formation. CONCLUSION Core fucosylation play

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