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https://www.selleckchem.com/products/tng260.html 05 ±12.49 vs. 69.78 ±13.73 mm Hg at P < 0.0001), max diastolic blood pressure (57.03 ±9.31 vs. 50.41 ±13.82 mm Hg; P < 0.0003), and max as well as min mean arterial blood pressure (46.8 ±10.13 vs. 41.39 ±15.46 mm Hg; P < 0.001) (27.88 ±5.71 vs. 26.14 ±7.35 mm Hg; P < 0.02). In newborns suffering from respiratory failure and treated with I-F, higher SpO2 values, lower heart rate, and higher arterial blood pressure coincide with success of the I-F therapy. In newborns suffering from respiratory failure and treated with I-F, higher SpO2 values, lower heart rate, and higher arterial blood pressure coincide with success of the I-F therapy. Current evidence suggests that intraoperative goal-directed haemodynamic therapy (GDT) should be considered for high-risk patients undergoing major gastrointestinal surgery. We aimed to evaluate if an algorithm using venoarterial carbon dioxide difference (CO2 gap) and pulse pressure variation (PPV) as therapeutic targets during GDT would decrease the major complications after gastrointestinal surgery. This was a before-and-after study (n = 204) performed in a tertiary hospital on patients who underwent elective open major gastrointestinal surgeries. The inclusion criteria were surgeries expected to last more than two hours, family and physician's agreement on total postoperative support, and survival expectancy of at least three months. The exclusion criteria were previous haemodynamic instability, presence of infection, cardiac arrhythmias, and emergency surgery. In the intervention group (IG), an algorithm was applied using fluids, dobutamine, and noradrenaline during the intraoperative period aiming at MAP > 65 mm Hg, SpO2 > 95%, CO2 gap < 6 mm Hg, and PPV < 13%. The control group (CG) comprised consecutive eligible patients who were operated by the same team before the institution of the algorithm. The rates of moderate and severe postoperative complications were lower in the IG (11

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