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https://www.selleckchem.com/products/ly2157299.html We compared risk of acute liver injury and mortality in patients with COVID-19 and current, past, and no HBV infection. This was a territory-wide retrospective cohort study in Hong Kong. Patients with COVID-19 between January 23, 2020, and January 1, 2021, were identified. Patients with hepatitis C or no HBsAg results were excluded. The primary outcome was mortality. Acute liver injury was defined as alanine aminotransferase or aspartate aminotransferase ≥2 × upper limit of normal (ULN; i.e., 80U/L), with total bilirubin ≥2 × ULN (i.e., 2.2mg/dL) and/or international normalized ratio ≥1.7. Of 5,639 patients included, 353 (6.3%) and 359 (6.4%) had current and past HBV infection, respectively. Compared to patients without known HBV exposure, current HBV-infected patients were older and more likely to have cirrhosis. Past HBV-infected patients were the oldest, and more had diabetes and cardiovascular disease. At a median follow-up of 14 (9-20) days, 138 (2.4%) patients died; acute liver injury occurred in 58 (1.2%), 8 (2.3%), and 11 (3.1%) patients with no, current, and past HBV infection, respectively. Acute liver injury (adjusted HR [aHR], 2.45; 95% CI, 1.52-3.96; P<0.001), but not current (aHR, 1.29; 95% CI, 0.61-2.70; P=0.507) or past (aHR, 0.90; 95% CI, 0.56-1.46; P=0.681) HBV infection, was associated with mortality. Use of corticosteroid, antifungal, ribavirin, or lopinavir-ritonavir (adjusted OR [aOR], 2.55-5.63), but not current (aOR, 1.93; 95% CI, 0.88-4.24; P=0.102) or past (aOR, 1.25; 95% CI, 0.62-2.55; P=0.533) HBV infection, was associated with acute liver injury. Current or past HBV infections were not associated with more liver injury and mortality in COVID-19. Current or past HBV infections were not associated with more liver injury and mortality in COVID-19.The field of tissue transplantation has revolutionized the treatment of patients with failing organs. Its success, thus far, has depended on comb

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