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https://www.selleckchem.com/products/trastuzumab-emtansine-t-dm1-.html The ultrawide band gap of diamond distinguishes it from other semiconductors, in that all known defects have deep energy levels that are less active at room temperature. Here, we present the effect of deep defects on the mechanical energy dissipation of single-crystal diamond experimentally and theoretically up to 973 K. Energy dissipation is found to increase with temperature and exhibits local maxima due to the interaction between phonons and deep defects activated at specific temperatures. A two-level model with deep energies is proposed to explain well the energy dissipation at elevated temperatures. It is evident that the removal of boron impurities can substantially increase the quality factor of room-temperature diamond mechanical resonators. The deep energy nature of the defects bestows single-crystal diamond with outstanding low intrinsic energy dissipation in mechanical resonators at room temperature or above.We present a lattice study of a 2-flavor U(1) gauge-Higgs model quantum field theory with a topological term at θ=π. Such studies are prohibitively costly in the standard lattice formulation due to the sign problem. Using a novel discretization of the model, along with an exact lattice dualization, we overcome the sign problem and reliably simulate such systems. Our work provides the first ab initio demonstration that the model is in the spin-chain universality class, and demonstrates the power of the new approach to U(1) gauge theories.We uncover that antiskyrmion crystals provide an experimentally accessible platform to realize a magnonic quadrupole topological insulator, whose hallmark signatures are robust magnonic corner states. Furthermore, we show that tuning an applied magnetic field can trigger the self-assembly of antiskyrmions carrying a fractional topological charge along the sample edges. Crucially, these fractional antiskyrmions restore the symmetries needed to enforc

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