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https://www.selleckchem.com/products/Sodium-butyrate.html Single-atom catalysts (SACs) exhibit intriguing catalytic performance owing to their maximized atom utilizations and unique electronic structures. However, the reported strategies for synthesizing SACs generally have special requirements for either the anchored metals or the supports. Herein, we report a universal approach of electrochemical deposition that is applicable to a wide range of metals and supports for the fabrication of SACs. The depositions were conducted on both cathode and anode, where the different redox reactions endowed the SACs with distinct electronic states. The SACs from cathodic deposition exhibited high activities towards hydrogen evolution reaction, while those from anodic deposition were highly active towards oxygen evolution reaction. When cathodically- and anodically-deposited Ir single atoms on Co0.8Fe0.2Se2@Ni foam were integrated into a two-electrode cell for overall water splitting, a voltage of 1.39 V was required at 10 mA cm-2 in alkaline electrolyte.Methylation of a conserved lysine in C-terminal domain of the molecular chaperone Hsp90 was shown previously to affect its in vivo function. However, the underlying mechanism remained elusive. Through a combined experimental and computational approach, this study shows that this site is very sensitive to sidechain modifications and crucial for Hsp90 activity in vitro and in vivo. Our results demonstrate that this particular lysine serves as a switch point for the regulation of Hsp90 functions by influencing its conformational cycle, ATPase activity, co-chaperone regulation, and client activation of yeast and human Hsp90. Incorporation of the methylated lysine via genetic code expansion specifically shows that upon modification, the conformational cycle of Hsp90 is altered. Molecular dynamics simulations including the methylated lysine suggest specific conformational changes that are propagated through Hsp90. Thus, methylation of

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