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https://www.selleckchem.com/products/ha130.html Ras-related dexamethasone-induced 1 ( ) is abnormally expressed in many solid cancers. However, its potential role in adults with B-cell acute lymphoblastic leukemia (B-ALL) is unclear. Therefore, we aim to clarify the abnormal expression of the tumor-associated biomarker, , as a potential target for diagnosis and prognosis in adult Philadelphia-negative B-ALL. The expression of was detected with RT-qPCR in 92 adults with de novo Ph-negative B-ALL and 40 healthy controls. The correlation between transcript levels and relapse was assessed. transcript levels in patients with Ph-negative B-ALL (median 81.76%, range 0.22%-1824.52%) were significantly higher than those in healthy controls (7.59%, 0.46%-38.66%; <0.0001). Patients with low transcript levels had a lower 5-year relapse-free survival (RFS, 47.5% [32.9%, 62.1%] vs. 63.1% [49.0%, 77.2%]; = 0.012) and a higher 5-year cumulative incidence of relapse (CIR, 52.0% [37.4%, 66.6%] vs. 36.2% [22.2%, 50.2%]; = 0.013) especially in patients receiving chemotherapy only. Multivariate analysis showed that a low transcript level was an independent risk factor for RFS (HR = 2.938 [1.427, 6.047], = 0.003) and CIR (HR = 3.367 [1.668, 6.796], = 0.001) in patients with Ph-negative B-ALL. transcript levels were significantly higher in patients with Ph-negative B-ALL and a low transcript level was independently correlated with increased relapse risk. RASD1 transcript levels were significantly higher in patients with Ph-negative B-ALL and a low RASD1 transcript level was independently correlated with increased relapse risk."Non-image-forming" (NIF) effects of light are mediated primarily by a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment, melanopsin (OPN4). These NIF functions include circadian entrainment, pupillary reflexes, and photic effects on sleep, mood, and cognition. We recently reported that mice of multiple genotypes exhib

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