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https://www.selleckchem.com/products/td139.html High acrylamide intake was associated with increased risks of ovarian and endometrial cancers in a relatively linear manner, especially among never-smokers. Conversely, little association was observed between acrylamide intake and breast cancer risk, with the exception of premenopausal women. Copyright ©2020, American Association for Cancer Research.BACKGROUND Although the poor prognosis and increasing incidence of pancreatic cancer highlight the need for prevention strategies, few lifestyle risk factors for pancreatic cancer have yet been identified. Soybeans contain various bioactive compounds. However, the association between soy food intake and pancreatic cancer risk remains unknown. METHODS The Japan Public Health Center-based Prospective Study (JPHC Study) is a cohort study conducted in a general Japanese population. To determine the association of soy food intake and pancreatic cancer incidence, we analyzed 90,185 participants who responded to a questionnaire on medical history and lifestyle factors, including dietary factors based on a food-frequency questionnaire in 1995-1998, using Cox proportional hazards models. RESULTS During a median follow-up of 16.9 years, 577 cases of pancreatic cancer were identified. In the multivariate-adjusted model, total soy food intake was statistically significantly associated with an increased risk of pancreatic cancer (hazard ratio [HR] for the highest versus lowest intake quartile 1.48; 95% confidence interval [CI] 1.15-1.92; P-trend = 0.007). Among soy foods, non-fermented soy food intake showed a statistically significant positive association with pancreatic cancer (HR 1.41; 95% CI 1.09-1.81; P-trend = 0.008), whereas fermented soy food intake showed no association (HR 0.96; 95% CI 0.73-1.26; P-trend = 0.982). CONCLUSIONS Higher intake of soy foods, particularly non-fermented soy foods, might increase pancreatic cancer risk. IMPACT This study is the first to report an asso

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