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Boswellic acids are the main constituents of Boswellia serrata gum. These comprises of four pentacyclic triterpenes, 11-keto-β-boswellic acid (KBA) being one of them. Comparing the extraction efficiency of KBA through microwave-assisted extraction (MAE) and ultrasoundassisted extraction (UAE) followed by optimizing the extraction process using response surface methodology (RSM) and validation of HPTLC. UAE and MAE of KBA were carried out employing methanol as extracting solvent. Working out the better mode of extraction, single factorial experiments were conducted for further optimization. Design expert software was used for optimization purpose where solvent to drug ratio, extraction temperature and extraction time were taken as input variables. Quantification of KBA in each extract was done through High Performance Thin Layer Chromatography (HPTLC) and the method was validated as per International Council for Harmonization (ICH) guidelines. UAE stood out to be better mode of extraction for KBA. Solvent to drug ratio of 21.54 mL/gram, extraction temperature of 45.12°C and extraction time of 10.02 minutes were established as optimum conditions which yielded 8.59%w/w of KBA. Regarding HPTLC, the Rf value of KBA was measured and correlation coefficient was calculated from standard curve. Accuracy, precision and recovery were found within limits. From this study, it was concluded that a non-thermal method is better choice of extraction for KBA. All the input variables significantly affected KBA content which was confirmed by model fitting. Moreover, HPTLC method was developed for quantification of KBA which was found to be accurate, reliable and highly sensitive. From this study, it was concluded that a non-thermal method is better choice of extraction for KBA. All the input variables significantly affected KBA content which was confirmed by model fitting. Moreover, HPTLC method was developed for quantification of KBA which was found to be accurate, reliable and highly sensitive. Virus nanoparticles have been extensively studied over the past decades for theranostics applications. Viruses are well-characterized, naturally occurring nanoparticles that can be produced in high quantity with a high degree of similarity in both structure and composition. The plant virus cowpea mosaic virus (CPMV) has been innovatively used as a nanoscaffold. Utilization of the internal cavity of empty virus-like particles (VLPs) for the inclusion of therapeutics within the capsid has opened many opportunities in drug delivery and imaging applications. The encapsidation of magnetic materials and anticancer drugs was achieved. CPMV denotes molecules attached to the external surface of CPMV and CPMV denotes molecules within the interior of the capsid. Here, the generation of novel VLPs incorporating iron-platinum nanoparticles CPMV and cisplatin (Cis) ( CPMV ) is reported. CPMV have a cytotoxic IC of CPMV on both A549 and MDA-MB-231 cell lines of 1.8 μM and 3.9 μM respectively after 72 hours of incubation. The CPMV were prepared as potential MRI contrast agents. Cisplatin loaded VLP ( CPMV ) is shown to enhance cisplatin cytotoxicity in cancer cell lines, and its potency increased 2.3-folds. Cisplatin loaded VLP (TCPMVCis) is shown to enhance cisplatin cytotoxicity in cancer cell lines, and its potency increased 2.3-folds. Production of light olefins from methanol was studied over SAPO-34 molecular sieves exploring the effect of mono and dual templates. Herein, the single templates of TEA, morpholine and mixed template of TEA/morpholine (equal molar ratio of TEA and morpholine) were used to synthesize SAPO-34 catalysts. The prepared samples were prepared via hydrothermal synthesis method and characterized with XRD, FESEM, PSD, EDX, BET and FTIR techniques. It was found that the crystallinity decreased upon applying TEA as template and also it can be noted that the intensity of the SAPO-34 phase peaks increased by increasing the morpholine in template mixture. Production of much smoother particles for the catalyst synthesized with binary template mixture of TEA/morpholine can be depended on the crystallinity increase. Si incorporation value was decreased for the catalyst with a major phase of SAPO-5 (topological structure of AFI). It is indicative that the TEA application would facilitate the formation of AFI structure which is incapable of the incorporating higher amounts of Si in to the crystallite framework. The nature of the template determines the morphology of final product due to different rate of crystal growth obtained in accordance with XRD and FESEM results. https://www.selleckchem.com/products/valproic-acid.html Therefore, the catalyst synthesized with TEA/morpholine mixture shows the best performance among synthesized samples in terms of life time in the MTO process sustaining light olefins selectivity at higher values (about 90% after 630 min TOS). The nature of the template determines the morphology of final product due to different rate of crystal growth obtained in accordance with XRD and FESEM results. Therefore, the catalyst synthesized with TEA/morpholine mixture shows the best performance among synthesized samples in terms of life time in the MTO process sustaining light olefins selectivity at higher values (about 90% after 630 min TOS). Various effects of Astaxanthin was shown in the studies including its antioxidant, anti-inflammatory, anti-tumor and immunregulator effects. The aim of this study was to evaluate the beneficial effects of Astaxanthin on renovascular occlusion induced renal injury and to investigate the possible mechanisms. The rats were randomly assigned into three groups as follows Group 1 control group (n=12), Group 2 renal ischemiareperfusion injury group (n=12), Group 3 renal ischemia-reperfusion + asthaxantine treated group (n=12). The control group and the renal ischemia-reperfusion group were given 2cc/kg/g olive oil for 7 days before establishing ischemia to renal tissue. Astaxanthin dissolved in olive oil was given orally to the renal ischemia+astaxanthin group for 7 days before inducing renal ischemia. Caspase-(3, 8, 9), GSH, SOD, Total Thiol, TNF-α, IL-6, 8-OHdG were performed for each group. Renal IRI was verified by analysing the pathological changes of renal tissues and the renal functions after renal reperfusion.
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