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https://www.selleckchem.com/products/seclidemstat.html Mann-Whitney U or Wilcoxon signed-rank tests and multiple regressions were applied (α=0.05). RESULTS Maxillary inter-premolar widths (first or second) expanded approximately 3mm after traction of unilateral or bilateral MIC (P>0.05). Changes in hemi-arch widths between palatal (1.67mm) versus buccal (1.90mm) MIC were similar (P>0.05). In unilateral impaction, the transversal changes on the affected side were 2mm versus almost 1mm observed in the unaffected side (P less then 0.05). Finally, the multiple linear regressions were identified to the ANB angle, the impaction sectors and the distance from middle raphe to the cusp tip of MIC as influential variables. CONCLUSION The maxillary inter-premolar widths increase after traction of MIC without differences between type or location of impaction. In addition, the transverse change in the affected side in unilateral MIC is greater than the unaffected side resolving the earlier transverse asymmetry. BACKGROUND AND AIMS Laterally spreading tumors (LSTs) are originally classified into 4 subtypes. Pseudo-depressed nongranular types (LSTs-NG-PD) are gaining attention because of their high malignancy potential. Previous studies discussed the classification of nongranular (LST-NG) and granular types (LST-G); however, the actual condition or indication for endoscopic treatment of LSTs-NG-PD remains unclear. We aimed to compare the submucosal invasion pattern of LSTs-NG-PD with the other 3 subtypes. METHODS A total of 22,987 colonic neoplasms including 2822 LSTs were resected endoscopically or surgically at Showa University Northern Yokohama Hospital. In these LSTs, 322 (11.4%) were submucosal invasive carcinomas. We retrospectively evaluated the clinicopathological features of LSTs divided into 4 subtypes. In 267 LSTs resected en bloc, their submucosal invasion site was further evaluated. RESULTS The frequency of LSTs in all colonic neoplasms was significantly higher in fema

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