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https://www.selleckchem.com/products/forskolin.html 0±7.64% for GSH and 98.5±12.7% for GSSG). Notable sample stability at -80°C was evident for GSH up to 55 weeks and GSSG up to 46 weeks, with average CVs less then 15% and less then 10%, respectively. This article is protected by copyright. All rights reserved.Herb processing is a typical pharmaceutical preparation process for traditional Chinese medicine. After processing, its clinical applications and pharmacological effects vary greatly, which is most commonly attributed to the changing chemical properties between raw herb and processed products. In this work, a total of 53 chemical compounds were detected, among which 17 compounds were identified as discriminatory chemicals between raw and wine-processed Scutellaria baicalensis, and 10 components were identified as chemical markers with an accumulative content contribution of 88.75%. In addition, this work revealed the best wine-processed time was 18 min by investigating the changes of chemical markers in S. baicalensis during processing. This work demonstrated that ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry coupled with multiple statistical strategies is an effective approach for screening and identifying discriminatory chemical markers in complex traditional Chinese medicine. This article is protected by copyright. All rights reserved.PURPOSE This work aims to establish a classification framework for the diagnosis of mild cognitive impairment (MCI) at different stages (early MCI and late MCI) through direct analysis of resting-state functional magnetic resonance imaging (rs-fMRI) signals and using the accuracy (total correct rate), specificity (correct rate of late MCI) and sensitivity (correct rate of early MCI) to validate its classification performance. METHODS All fMR images of subjects were parcellated into 116 regions of interest (ROIs) by applying the Anatomical Automatic Labeling (AAL) template, and the average

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