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https://www.selleckchem.com/products/Honokiol.html The coronavirus disease 2019 (COVID-19) turned into a pandemic in short-time with multi-dimensional effects on human lives. The containment of this infection has become a big challenge in all countries due to its rapid spread. In this situation, when there is no definitive cure or any vaccine available to overcome COVID-19, it is prudent for the world to live with this deadly virus for the many months to come. Hence, it is imperative for the dental professionals, particularly orthodontists, to modify their approach to learn the new normal of practicing dentistry.Implant insertion into an atrophic knife-edge ridge with non-simultaneous extraction of anterior and posterior teeth is challenging; this is why bone regeneration before implant placement is of great importance. One of the best sources for reconstruction is an intraoral autogenous bone graft. A composite bone graft is a combination of autogenic bone and mucosal flap that provides adequate blood supply and fixation compared to conventional (from the mandibular symphysis or ramus) and extraoral bone grafts. Bone remodeling after tooth extraction results in decreased ridge volume and complicates implant placement. Platelet-rich fibrin (PRF) is a rich source of autogenous cytokines and growth factors; it has been proven to effectively improve soft tissue healing and hard tissue regeneration. This study sought to compare the clinical application of freeze-dried bone allografts (FDBA) and PRF for alveolar ridge preservation after tooth extraction. This clinical trial was conducted on 32 patients presenting for the extraction of hopeless non-molar teeth. The teeth were extracted with minimal trauma, and the samples were randomly divided into two groups (n=16). Tooth sockets were filled with either FDBA or PRF (prepared using 10cc of the patient's blood). Bone regeneration was assessed by evaluating changes in horizontal and vertical bone dimensions after 12 weeks (

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