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https://www.selleckchem.com/products/bms-911172.html In vivo chemical reactions activated by the tumor microenvironment (TME) are particularly promising for antitumor treatments. Herein, employing Cu2-xSe-Au Janus nanoparticles (NPs), photothermal conversion-coordinated Fenton-like and photocatalytic reactions are demonstrated in vitro/vivo. The amorphous form of Cu2-xSe and the catalytic effect of Au benefit the OH generation, and the photo-induced electron‒hole separation of the Janus NPs produces additional OH. The plasmonic electrons of Au facilitate the conversion from Cu2+ to Cu+. Both Cu2-xSe and Au contributes to the efficient photothermal conversion, further promoting the reactions. As a result, the H2O2 utilization rate is largely increased, and remarkable generation of reactive oxygen species is achieved by cell endogenous H2O2in vitro/vivo. A competent tumor inhibition effect is afforded, with high-contrast multimodal imaging. This work opens up the route synergistically integrating photothermal therapy with chemodynamic therapy and photocatalytic therapy into tri-combination antitumor therapy, simply by heterojunction of semiconductor and noble metal.Carbon dots (CDs) are emerging as powerful nanoprobes for multiple-model bioimaging. Nowadays, orthotopic xenograft models attract increasing attention because of their superiorities of duplicating the tumor microenvironment. However, compared with the extensive study of subcutaneous xenograft tumors, less attention has been paid to CDs for in vivo orthotopic tumor imaging. Furthermore, it is very desirable for a nanoprobe to achieve preferential accumulation at the tumor site and efficient renal clearance. In this work, a novel kind of Hafnium-doped CDs (HfCDs) were successfully prepared via a simple one-pot pyrolysis method. The significant advantages including robust stability, good biocompatibility, excellent water solubility, remarkable computed tomography (CT) contrast performance and preferential tum

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