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https://www.selleckchem.com/products/ml351.html BACKGROUND Bacterial infections are a growing problem worldwide causing morbidity and mortality mainly in developing countries. On the other hand, the increased number of microorganisms, developing multiple resistances to known drugs, due to abuse of antibiotics, is another serious problem. This problem becomes more serious for immunocompromised patients and those who are often disposed to opportunistic fungal infections. OBJECTIVE The objective of this manuscript is to give an overview of new findings in the field of antimicrobial agents among five-membered heterocyclic compounds. These hetrocyclic compounds especially five-membered attracted the interest of scientific community not only their occurrence in nature but also due to their wide range of biological activities. METHOD To reach our goal a literature survey that covers the last decade was performed. RESULTS As a result, recent data on biological activity of thiazole, thiazolidinone, benzothiazole and thiadiazole derivatives are mentioned. CONCLUSION It should be mentioned that despite the progress in the development of new antimicrobial agents there is still room for new findings. Thus, research still continues. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.A complex interplay of peripheral and central signaling mechanisms within the body of an organism maintains energy homeostasis. In addition, energy/food intake is modified by various external factors (e.g., palatability, food availability, social and environmental triggers). Highly palatable foods can provoke maladaptive feeding behavior, which in turn disrupts normal homeostatic regulation resulting in numerous health consequences. Furthermore, neuroendocrine peptides, traditionally considered to regulate appetite and energy homeostasis, also control the intake and reinforcing properties of alcohol and drugs of abuse. Therefore, dysregulated eating as a re

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