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https://www.selleckchem.com/products/azd2014.html The Arabian Gulf is a dynamic environment with unique habitats located in the Middle East. The inhabitants of this ecosystem have historically been understudied and a lack of reliable toxicity data exists to benchmark their sensitivities. Current international testing guidelines (i.e. Organization for Economic Co-Operation and Development (OECD), International Standard Organization (ISO), Environmental Protection Agency (EPA), etc.) do not reference relevant species for this region of the world. This research focuses on developing standard test conditions for relevant test organisms indigenous to the Middle East region while maintaining general agreement with international testing guidelines. A copepod, cyanobacteria and juvenile killifish were selected as local test organisms to perform acute exposures to 4 Aromatic Hydrocarbons (AHs) ranging in log KOW from 3.88-5.19, 1-methylnaphthalene, phenanthrene, biphenyl and octahydrophenanthrene. Acute test durations were 48, 72 and 96 h and generally followed ISO 14669, OECD 201 and 203 for the copepod, algae and killifish respectively. To deliver and maintain controlled exposure concentrations, a passive dosing (PD) format was employed. PD effectively maintained aqueous exposure concentration of the AHs tested over the test duration. Effects data were comparable to literature values for similar taxonomic groupings. Critical target lipid body burden's for test species used were calculated and found to be in agreement with those predicted by the Target Lipid Model. The nerve growth factor (NGF), a member of the neurotrophins family, plays an important role in the nervous system but also in the reproductive apparatus and in sperm traits. The aim of this review is to summarize the effect of NGF on sperm functions of mammals. NGF was detected in seminal plasma of many animal species and its receptors, TrkA and p75NTR, are present in both epididymal and ejaculated sperm. The NG

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