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https://www.selleckchem.com/products/odq.html Pathological studies also showed that sepsis led to the liver tissue injuries, which can be reduced by treatments. Conclusion Sepsis caused oxidative stress in the liver tissue, but the administration of DDW and DDW plus RD essential oil can be useful to prevent and heal these injuries.Objectives The aim of the work was to substantiate the use of a newly created oral care product in the treatment of periodontal disease reconstructed against the background of hyperacidic gastritis under the conditions of tobacco smoke intoxication. Materials and methods The study was conducted in 2 stages. In the first stage, all experimental animals were divided into 4 groups 1) intact, 2) with simulated periodontitis, 3) with reproduced periodontitis against the background of reproduced hyperacidic gastritis, 4) with reproduced periodontitis against the background of hyperacid gastritis under the conditions of tobacco smoking. Biochemical studies of gum homogenate with periodontitis in rats were conducted to determine the impact of stomach pathology and tobacco smoke as endogenous and exogenous risk factors. In stage 2, the effectiveness of local therapy with the use of the newly created oral care product and a comparator was studied in rats with reproduced periodontitis against the background of hyperacidncomitant stomach pathology, hyperacidic gastritis.Objectives Some novel 1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-(substituted phenoxy)propan-2-ol derivatives (3a-g) were designed and synthesized. Materials and methods Compounds 3a-g were obtained by refluxing ornidazole (1) with the corresponding phenolic compounds (2a-g) in the presence of anhydrous K2CO3 in acetonitrile. Results Following the structure elucidation, the in vitro antimicrobial activity and cytotoxic effects of compounds 3a-g on K562 leukemia and NIH/3T3 mouse embryonic fibroblast cells were measured. As a part of this study, the compliance of the compounds with the dru

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