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https://www.selleckchem.com/products/vtx-27.html 001). Median (IQR) numbers of hospitalizations in follow up were significantly less than that of prior to surgical resection 0 (0,0) vs 1(1,1) (P=0.016) in children with CPAM. Lung hypoplasia was the most common congenital lung malformation in our setup. Detection of malformation during antenatal period was poor. Age of diagnosis and surgical intervention is often delayed. Regular follow up and definitive and/or supportive management decreased the morbidity. Lung hypoplasia was the most common congenital lung malformation in our setup. Detection of malformation during antenatal period was poor. Age of diagnosis and surgical intervention is often delayed. Regular follow up and definitive and/or supportive management decreased the morbidity. There is a paucity of data on use of dexmedetomidine as a sedative agent in mechanically ventilated children. To compare the efficacy of dexmedetomidine and midazolam for sedation in mechanically ventilated children aged 1 month - 15 years. Secondary objectives were to compare the need for top-up doses of fentanyl and paralytic agents, duration of mechanical ventilation, ICU stay and hospital stay, and adverse events. Open label, non-inferiority, randomized controlled trial. PICU of a tertiary care teaching hospital in India. Consecutive children aged 1 month to 15 years who were mechanically ventilated. Children were randomized to either dexmedeto-midine or midazolam and the doses were titrated to maintain target sedation score of 4 or 5 as measured by Penn State Children Hospital Sedation algorithm. The percentage of time spent in level 4 or 5 of Penn State Children Hospital sedation algorithm for ventilated children. 49 children were randomized (24 to 'midazolam group' and 25 to 'dexmedetomidine group'). There was no difference in the percentage of time spent in the targeted sedation between the groups [midazolam 67.3% (18.8) vs. dexmedetomidine 56.3 %. (28.6); P=0.12]. The absol

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