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https://www.selleckchem.com/products/recilisib.html 001). The predictive accuracy of the indices mentioned above were 0.660, 0.802, 0.852, 0.837, 0.784, 0.929, and 0.929, respectively. Following LDA supplementation, URPL patients showed a significant reduction in resistance to endometrial and uterine artery blood flow (P less then 0.001). CONCLUSION URPL patients had impaired uterine perfusion. Doppler parameters are valuable in predicting women at high risk of URPL. LDA could be effective in improving endometrial receptivity. This article is protected by copyright. All rights reserved.Dr. Ioannidis may cause irreparable harm from recent publications. Novel coronavirus, by definition, arrives without precedence and therefore the reliable data Ioannidis craves. The unshakable facts regarding the Covid-19 consists of the number of deaths, country populations, and the dataset from the Diamond Princess cruise. This article is protected by copyright. All rights reserved.BACKGROUND More than 30 causative genes have been identified in familial and sporadic Amyotrophic Lateral Sclerosis (ALS). The next-generation sequencing (NGS) is a powerful and groundbreaking tool to identify disease-associated variants. Despite documented advantages of NGS, its diagnostic reliability needs to be addressed in order to use this technology for specific routine diagnosis. MATERIAL AND METHODS Literature database was explored to identify studies comparing NGS and Sanger sequencing for the detection of variants causing ALS. We collected data about patients' characteristics, disease type and duration, NGS and Sanger properties. RESULTS More than 200 bibliographic references were identified, of which only 14 studies matching our inclusion criteria. Only 2 out of 14 studies compared results of NGS analysis with the Sanger sequencing. Twelve studies screened causative genes associated to ALS using NGS technologies and confirmed the identified variants with Sanger sequencing. Overall, data about m

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