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https://www.selleckchem.com/products/cc-92480.html Approximately 70% of breast cancers are estrogen receptor (ER)-positive and treated with endocrine therapy. A commonly used treatment agent, tamoxifen, shows high efficacy for improving prognosis. However, approximately one-third of patients treated with tamoxifen develop resistance to this drug. Here, we investigated the function of general control non-derepressible 5 (GCN5) and its downstream effectors in tamoxifen-resistant (TamR) breast cancer. TamR-MCF7 breast cancer cells maintained high GCN5 levels due to its attenuated proteasomal degradation. GCN5 overexpression upregulated amplified in breast cancer 1 (AIB1) expression, resulting in decreased p53 stability and tamoxifen resistance. Conversely, the sensitivity of GCN5-AIB1-overexpressing MCF7 cells to tamoxifen was restored by forced p53 expression. An in vivo study demonstrated a positive correlation between GCN5 and AIB1 and their contribution to tamoxifen resistance. We concluded that GCN5 promotes AIB1 expression and tamoxifen resistance in breast cancer by reducing p53 levels, suggesting the utility of GCN5 and its downstream effectors as therapeutic targets to either prevent or overcome tamoxifen resistance in breast cancer.Vegetarianism, which is increasingly widespread in Western societies, is underpinned by various motivations (ethical, environmental, health concerns …) and the question of its association with eating disorders continues to divide the literature. This cross-sectional study aimed to explore and compare eating motives/attitudes and bodily preoccupations of vegetarian and omnivorous participants from the general population. Forty-nine vegetarians and 52 omnivores, aged between 18 and 70 years, completed a battery of questionnaires including sociodemographic characteristics, Body Mass Indexes (BMI - current, ideal, lifetime lowest, and lifetime highest), the Food Choice Questionnaire (FCQ), the Eating Attitudes Test-26 (EAT-26), and the

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