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https://www.selleckchem.com/products/LAQ824(NVP-LAQ824).html However, the QoL related to low socio-economic factors gave mixed results and physical activity, education and type of footwear can influence the outcomes. There is a general gender-dependent higher prevalence of DFS in men, although it depends on the geographical area. DFS often co-occurs with other diabetes-induced complications (retinopathy, nephropathy and cardiovascular disorders) and comorbid obesity generally worsens it. CONCLUSIONS Accessibility to health services aimed at reducing inequalities and constant health education and promotion and care regarding psychological and socio-economic issues should be continuously undertaken for individuals with DFS in order to improve their QoL. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Adhesion G Protein-Coupled Receptor 116 (GPR116) is an orphan receptor known for the function and variety of extracellular signalling, cell- cell adhesion, angiogenesis and cell migration. Many studies have shown that different GPCRs are over expressed in several cancers. GPR116 could be a pharmacologically important drug target for triple negative breast cancer (TNBC), because previous studies have found that the knockdown of GPR116 results in suppression of cell migration and invasion. However no drugs targeting GPR116 were identified until now. OBJECTIVE In this study, GPR116 is considered as a selective target for triple negative breast cancer treatment. METHODS Computational molecular characterisation of GPR116 was carried out to identify crucial amino acids. In this regard Food and Drug Administration (FDA) approved breast cancer drugs were selected as ligands and performed molecular docking study with insilico protein structure of GPR116 receptor. Molecular dynamics simulations have been useal amino acid . To investigate further in vitro/in vivo assay to confirm the active site in breast cancer functional r

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