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https://www.selleckchem.com/products/BMS-536924.html Considering costs for retraining, the breakeven point is reached if the TIP prevents retraining in approximately 64% of participants. CONCLUSIONS The decreased COI in this long-term evaluation indicates that the TIP is cost-effective in patients with severe OSD. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.BACKGROUND Metal work apprentices (MWAs) frequently develop work-related hand eczema (HE). OBJECTIVES To evaluate the effect of health education on incidence of work-related HE in MWAs and to assess confounding factors. MATERIALS/METHODS In a prospective controlled intervention study, 131 MWAs received educational training on prevention of HE, whereas 172 MWAs and 118 office work apprentices served as controls. At baseline and during three yearly follow-ups, questionnaires were completed and hands were examined. Saliva samples were collected for assessment of filaggrin (FLG) null mutations and an explorative genome-wide association study (GWAS), and levels of various cytokines were assessed from stratum corneum samples. RESULTS The 2-year and 3-year incidence of HE in the metalwork control group was 20.9% and 32.6%, respectively, which was significantly higher than in the intervention group (odds ratio [OR] 2.63, 95% confidence interval [CI] 1.31 to 5.28, P  less then  .01 and OR 3.47, 95% CI 1.88 to 6.40, P  less then  .0001). The knowledge score was higher in unaffected MWAs (P  less then  .05). Other factors significantly associated with developing HE in MWAs were smoking cigarettes (P  less then  .01) and FLG mutations (P  less then  .001). No significant links were found regarding epidermal cytokine levels and GWAS. CONCLUSIONS Health education is effective in primary prevention of HE in MWAs. Individual factors should be considered in targeted counseling. © 2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.BAC

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