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https://www.selleckchem.com/products/MLN8237.html The use of M. officinalis L. leaf dried extract in animal feed at the proposed use level does not raise significantly the exposure levels of the consumer for compounds derived from this plant. However, in the absence of adequate data on genotoxicity, the Panel cannot conclude on the safety for the consumer. In the absence of specific studies, the FEEDAP Panel cannot conclude on the safety of the additive for the user. M. officinalis L. is a native species to Europe and its use in animal nutrition is not expected to pose a risk for the environment. Since M. officinalis L. and its extracts are recognised to flavour food and its function in feed would be essentially the same as that in food, no further demonstration of efficacy is considered necessary for the extract.Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of Ecobiol® when used as a zootechnical additive in feed for chickens for fattening and chickens reared for laying at 1.0 × 109 colony forming units (CFU)/kg feed. Ecobiol® is the trade name for a feed additive based on Bacillus amyloliquefaciens CECT 5940, currently authorised for use in chickens for fattening. This opinion concerns the renewal of the authorisation of Ecobiol® for chickens for fattening and the evaluation of the new use with chickens reared for laying. The applicant has provided evidence that the additive currently in the market complies with the existing conditions of authorisation. The FEEDAP Panel concludes that Ecobiol® is safe under the current conditions of authorisation for the target species (chickens for fattening and chickens reared for laying), consumers of products from animals fed the additive and the environment. Ecobiol® is not irritant to skin/eye or a skin sensitiser but should be considered a potential respiratory sensitiser. D

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