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https://www.selleckchem.com/products/nmda-n-methyl-d-aspartic-acid.html miR-27a augmentation via tail-vein injection of miR-27a mimic in high cholesterol diet-fed Apoe -/- mice shows down-regulation of hepatic Hmgcr and plasma cholesterol levels. Pathway and gene expression analyses show that miR-27a also targets several other genes (apart from Hmgcr) in cholesterol biosynthesis pathway. Taken together, miR-27a emerges as a key regulator of cholesterol biosynthesis and has therapeutic potential for clinical management of hypercholesterolemia. Copyright © 2020 American Society for Microbiology.Stress granules (SGs) are cytoplasmic aggregates formed upon stress when untranslated messenger ribonucleoproteins accumulate in the cells. In a GFP-library screening of the fission yeast SG proteins, Puf2 of the PUF family of RNA-binding proteins was identified that is required for SG formation after deprivation of glucose. Accordingly, puf2 mutant is defective in recovery from glucose starvation with a much longer lag to re-enter the cell cycle. In keeping with these results, Puf2 contains several low-complexity and intrinsically disordered protein regions with a tendency to form aggregates and, when over-expressed, represses translation to induce aggregation of poly(A) binding protein Pabp, the signature constituent of SGs. Intriguingly, over-expression of Puf2 also enhances the structure of processing bodies (PBs), another type of cytoplasmic RNA granules, a complex of factors involved in mRNA degradation. We demonstrate, in this study, a function of the fission yeast PB in SG formation and Puf2 may provide the link of these two structures. Copyright © 2020 American Society for Microbiology.The chloroplast glutamyl-tRNA (tRNAGlu) is unique in that it has two entirely different functions. In addition to acting in translation, it serves as substrate of glutamyl-tRNA reductase, the enzyme catalyzing the committed step in the tetrapyrrole biosynthetic pathway. How the tRNAGlu p

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