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https://www.selleckchem.com/products/mek162.html Rhodopsin, a prototypical G-protein-coupled receptor, is responsible for scoptic vision at low-light levels. Although rhodopsin's photoactivation cascade is well understood, it remains unclear how lipid and zinc binding to the receptor are coupled. Using native mass spectrometry, we developed a novel data analysis strategy to deconvolve zinc and lipid bound to the proteoforms of rhodopsin and investigated the allosteric interaction between lipids and zinc binding. We discovered that phosphatidylcholine bound to rhodopsin with a greater affinity than phosphatidylserine or phosphatidylethanolamine, and that binding of all lipids was influenced by zinc but with different effects. In contrast, zinc binding was relatively unperturbed by lipids. Overall, these data reveal that lipid binding can be strongly and differentially influenced by metal ions.Wealth accumulation is a key dimension of ethno-racial stratification, and, among immigrants, an important indicator of incorporation. Dramatically low assets among immigrant Latinos is thus a pressing concern, necessitating a better understanding of the social forces that shape wealth assimilation. Drawing on a survey of Latino immigrants in Durham, NC, I argue for the importance of a transnational perspective on wealth for immigrant populations. Nationally representative surveys designed to assess inequality among the general population generally lack information on wealth held abroad, which accounts for the lion's share of assets held by immigrants in our sample. Likewise, these data sources rarely have information on factors salient to immigrants, particularly legal status and informal employment. Finally, I show that the socio-demographic characteristics central to life-cycle wealth models operate in different ways for U.S. and foreign assets, and for men and women. For instance, while household earnings and duration of Durham residence are associated with greater U.S. asse

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