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https://www.selleckchem.com/products/elacridar-gf120918.html BACKGROUND Environmental chemicals like phthalates, phenols and parabens may impact children's immune development and contribute to risk of atopic diseases and asthma. OBJECTIVE To evaluate the associations between prenatal and childhood phthalate exposure and child atopic diseases at the age of 9 years. METHODS The current analysis is restricted to 145 mother-child pairs from the prospective Polish Mother and Child cohort (REPRO_PL). Phthalate metabolite levels were assessed in the urine samples collected from mothers during the 3 rd trimester of pregnancy and from children at age of 2 and 9 years. For the appropriate recognition of children's health status, a questionnaire was administered to the mothers and completed with information from the medical chart of each child. The clinical examination was performed by a pediatrician/allergist in the presence of the mother or a relative. RESULTS Higher urine concentration of 5oxo-MEHP increased the risk of food allergy in children at 9 years of age (O R =1.75, 95% CI1.19-2.57;p = 0.004) and decreased the risk of atopic dermatitis (OR=0.49,95%CI0.27-0.87;p =0.015). For 5OH-MEHP increased the risk of atopic dermatitis was observed OR = 1.90,95%CI1.183.05;p=0.008). Higher urine concentration of MBzP increased the risk of asthma in children (OR = 1.67,95%CI1.08-2.58; p = 0.021) but the risk of asthma decreased when the concentration of MEHP was higher (OR = 0.64,95% CI10.43-0.97;p=0.035). CONCLUSIONS Our study has not provided clear evidence for the negative impact of phthalate exposure during pregnancy and within the 9 years after birth on allergic diseases in children. OBJECTIVE Maternal heart disease (HD) complicates 1-4 % of pregnancies and is associated with adverse maternal and fetal outcomes. Although vaginal birth is generally recommended in the guidelines, cesarean section (CS) rates in women with HD are often high. Aim of the present study was to evaluat

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