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ast Cancer in the Northeastern Part of West Malaysia. Sex Med 2021;9100351.Rhinocerotidae represents a common element in the Eurasian Pleistocene faunas. Origin, dispersal route, and biochronology of several species are still poorly understood due to gaps in the fossil record, in particular from central Eurasia. A remarkable collection of rhinoceros remains was recovered from the Early Pleistocene site of Dmanisi (Georgia). This collection is unique for the Early Pleistocene Rhinocerotidae records due to its abundance in remains, its age (ca 1.8 Ma) and geographic position (between Eastern and Western Eurasia). Two crania, which display some different morphological traits, are assigned to two different morphotypes and investigated by means of geometric morphometrics using landmarks and semilandmarks. Shapes in lateral and dorsal views of different Rhinocerotini species are compared with the studied crania to infer paleoecological information. The shape in the lateral view reflects ecological niche, in particular feeding type from browsing to grazing, and it also represent taxonomic discrimination. Morphotypes 1 and 2 from Dmanisi fall in two different clusters, corresponding to two different species, notably in lateral view. The results suggest a niche partitioning during the Early Pleistocene of Dmanisi between a browse-dominated and a grass-dominated mixed feeders, or possibly the presence of two ecomorphotypes of the same species. A comprehensive update of the Early Pleistocene occurrences of Eurasian Rhinocerotidae is reported in the discussion on the paleoecology of the extinct Northern Eurasian rhinocerotines. To test whether change in motor evoked potential (ΔMEP) induced by continuous theta-burst stimulation (cTBS) of motor cortex (M1) distinguishes adults with autism spectrum disorder (ASD) from neurotypicals, and to explore the contribution of two common polymorphisms related to neuroplasticity. 44 adult neurotypical (NT) participants (age 21-65, 34 males) and 19 adults with ASD (age 21-58, 17 males) prospectively underwent M1 cTBS. Their data were combined with previously obtained results from 35 NT and 35 ASD adults. ΔMEP at 15 minutes post-cTBS (T15) was a significant predictor of diagnosis (p=0.04) in the present sample (n=63). T15 remained a significant predictor in a larger sample (n=91) and when partially imputed based on T10-T20 from a yet-greater sample (N=133). T15 also remained a significant predictor of diagnosis among brain-derived neurotrophic factor (BDNF) Met+ and apolipoprotein E (APOE) ε4- subjects (p's<0.05), but not among Met- or ε4+ subjects (p's>0.19). ΔMEP at T15 post-cTBS is a significant biomarker for adults with ASD, and its utility is modulated by BDNF and APOE polymorphisms. M1 cTBS response is a physiologic biomarker for adults with ASD in large samples, and controlling for BDNF and APOE polymorphisms can improve its diagnostic utility. M1 cTBS response is a physiologic biomarker for adults with ASD in large samples, and controlling for BDNF and APOE polymorphisms can improve its diagnostic utility. Navigated transcranial magnetic stimulation (nTMS) is targeted at different cortical sites for diagnostic, therapeutic, and neuroscientific purposes. Correct identification of the cortical target areas is important for achieving desired effects, but it is challenging when no direct responses arise upon target area stimulation. We aimed at utilizing atlas-based marking of cortical areas for nTMS targeting to present a convenient, rater-independent method for overlaying the individual target sites with brain anatomy. We developed a pipeline, which fits a brain atlas to the individual brain and enables visualization of the target areas during the nTMS session. We applied the pipeline to our previous nTMS data, focusing on depression and schizophrenia patients. Furthermore, we included examples of Tourette syndrome and tinnitus therapies, as well as neurosurgical and motor mappings. In depression and schizophrenia patients, the visually selected dorsolateral prefrontal cortex (DLPFC) targets were close to the border between atlas areas A9/46 and A8. In the other areas, the atlas-based areas were in agreement with the treatment targets. The atlas-based target areas agreed well with the cortical targets selected by experts during the treatments. Overlaying atlas information over the navigation view is a convenient and useful add-on for improving nTMS targeting. Overlaying atlas information over the navigation view is a convenient and useful add-on for improving nTMS targeting. Altered interhemispheric connectivity is implicated in the pathophysiology of schizophrenia (SCZ) and major depressive disorder (MDD) and may account for deficits in lateralized cognitive processes. We measured transcranial magnetic stimulation evoked interhemispheric signal propagation (ISP), a non-invasive measure of transcallosal connectivity, and hypothesized that the SCZ and MDD groups will have increased ISP compared to healthy controls. We evaluated ISP over the dorsolateral prefrontal cortex in 34 patients with SCZ and 34 patients with MDD compared to 32 age and sex-matched healthy controls. ISP was significantly increased in patients with SCZ and patients with MDD compared to healthy controls but did not differ between patient groups. https://www.selleckchem.com/products/gsk2830371.html There were no effects of antidepressant, antipsychotic, and benzodiazepine medications on ISP and our results remained unchanged after re-analysis with a region of interest method. Altered ISP was found in both SCZ and MDD patient groups. This indicates that disruptions of interhemispheric signaling processes can be indexed with ISP across psychiatric populations. These findings enhance our knowledge of the physiological mechanisms of interhemispheric imbalances in SCZ and MDD, which may serve as potential treatment targets in future patients. These findings enhance our knowledge of the physiological mechanisms of interhemispheric imbalances in SCZ and MDD, which may serve as potential treatment targets in future patients. To quantify effects of sleep and seizures on the rate of interictal epileptiform discharges (IED) and to classify patients with epilepsy based on IED activation patterns. We analyzed long-term EEGs from 76 patients with at least one recorded epileptic seizure during monitoring. IEDs were detected with an AI-based algorithm and validated by visual inspection. We then used unsupervised clustering to characterize patient sub-cohorts with similar IED activation patterns regarding circadian rhythms, deep sleep activation, and seizure occurrence. Five sub-cohorts with similar IED activation patterns were found "Sporadic" (14%, n=10) without or few IEDs, "Continuous" (32%, n=23) with weak circadian/deep sleep or seizure modulation, "Nighttime & seizure activation" (23%, n=17) with high IED rates during normal sleep times and after seizures but without deep sleep modulation, "Deep sleep" (19%, n=14) with strong IED modulation during deep sleep, and "Seizure deactivation" (12%, n=9) with deactivation of IEDs after seizures.
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