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https://www.selleckchem.com/products/trastuzumab-deruxtecan.html 06 ha. The lake has expanded to ~11 ha in 2019. Results from the GlabTop model suggest that the lake could grow further up to 12 ha in the future. Field-based geomorphic indicators suggest that the 2014 GLOF event resulted from a piping failure of the frontal moraine destroying numerous agricultural fields, some buildings, downstream infrastructure, and eroded natural channel embankments. The reconstruction of the event revealed that 25% of the lake waters drained out with a peak discharge of 470 m3s-1, inundating an area of ~4 km2 around Gya Village. However, a complete breaching of the terminal moraine could result in an event that would be 5.5 times larger than the 2014 GLOF. Therefore, this study could be useful not only in planning disaster-resilient infrastructure around proglacial lake environments in the cold-arid Ladakh but also in framing mitigation plans to reduce risk for vulnerable downstream communities.Guitarfishes and angelsharks are two of the most endangered elasmobranch groups. Despite this, limited knowledge exists regarding the effects of environmental contamination in these groups. For this reason, this study assessed the concentrations of metals in liver and muscle of three guitarfishes (Pseudobatos horkelii, P. percellens, and Zapteryx brevirostris) and one angelshark species (Squatina guggenheim) captured during the year of 2019 in one of the most impacted areas in South America the São Paulo State coast, Brazil, Southwest Atlantic. Cadmium (Cd) Chromium (Cr) Cupper (Cu) Iron (Fe), Mercury (Hg), and Lead (Pb) were determined by atomic spectrometry, with samples being previously acid digested. Among the non-essential metals, Cd had the highest mean concentrations for all species, followed by Pb and Hg, whereas Fe had the highest mean levels among the essential metals analyzed, followed by Cu and Cr. Liver and muscle samples had different concentrations, with liver presenting the

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