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https://www.selleckchem.com/products/BIBW2992.html ker for the diagnosis and treatment of ESCC. This study aimed to evaluate the role of F-fluorodeoxyglucose ( F-FDG) positron emission tomography (PET)/computed tomography (CT) in expression of tumor programmed death ligand-1 (PD-L1) expression and prognostic significance of F-FDG PET/CT at different PD-L1 status in patients with lung adenocarcinoma. Seventy-three patients with primary lung adenocarcinoma who received F-FDG PET/CT before treatment were retrospectively included in this study. Expression of tumor PD-L1, programmed death-1 (PD-1) and glucose metabolic parameters were evaluated. Tumor PD-L1 expression was positively correlated with maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), hexokinase II (HK-II) and glucose transporter 1 (GLUT-1) ( <0.0001 for all). SUVmax was a unique independent predictor of tumor PD-L1 expression, with an optimal cut-off value of 9.5. For all the patients, tumor stage ( 0.001) and SUVmax ( =0.009) were independent prognostic indicators of disease-free survival (DFS)/progression-free survival (PFS) while carcino-embryonic antigen (CEA) ( =0.003), Ki67 ( =0.042), PD-L1 ( =0.048) and TLG ( =0.004) were independent prognostic indicators of overall survival (OS). Tumor stage ( =0.004) and SUVmax ( =0.022) were independent prognostic indicators of DFS/PFS while TLG ( =0.012) and CEA ( =0.045) were independent prognostic indicators of OS in the PD-L1-positive group. In the PD-L1-negative group, tumor stage ( =0.002) and CEA ( =0.006) were unique independent prognostic indicators of DFS/PFS and OS, respectively. F-FDG PET/CT may potentially predict tumor PD-L1 expression and play a role in predicting prognosis of PD-L1/PD-1 immunotherapy in lung adenocarcinoma. 18F-FDG PET/CT may potentially predict tumor PD-L1 expression and play a role in predicting prognosis of PD-L1/PD-1 immunotherapy in lung adenocarcinoma. Rab27A and Rab27B, members of the Rab family of s

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