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https://www.selleckchem.com/products/rilematovir.html Interim positron emission tomography (iPET-2)-guided therapy following two cycles of ABVD chemotherapy has been developed for newly diagnosed classical Hodgkin lymphoma (cHL) patients in several prospective trials. In localized-stage cHL, radiotherapy cannot be omitted, even in iPET-negative patients after two or three cycles of ABVD, whereas two cycles of escalated BEACOPP regimens followed by involved nodular radiotherapy (30 Gy) is a useful treatment option for iPET-2 positive patients after two cycles of ABVD. In advanced-stage cHL, approximately 20% of cases were iPET-2 positive, and the switch to BEACOPP-based regimens was reported as a useful treatment option, with 3-year progression-free survival of approximately 60-65%, in iPET-2-positive patients in three clinical trials. Furthermore, the switch to AVD (omission of bleomycin after two cycles of ABVD) is a reasonable treatment option in iPET-2-negative patients, particularly those at risk for bleomycin lung toxicity in advanced-stage cHL. This review summarizes the current evidence regarding interim PET-guided therapy for newly diagnosed cHL patients.With pediatric-inspired chemotherapy, the survival of adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL) has improved. For standard-risk patients in the first complete remission (CR1), pediatric-inspired chemotherapy may be superior than allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, increased dose of steroid, vincristine, and L-asparaginase (L-Asp) in pediatric-inspired chemotherapy induces adverse events in certain number of adult ALL patients. Especially, the administration of L-Asp is often reduced to 60-70% for thrombosis or liver dysfunction. The optimal dose of these agents for adult ALL patients with higher age is under investigation. Moreover, minimal residual disease (MRD) >10-4 is a poor prognostic factor. The time point for the assess
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