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https://www.selleckchem.com/products/PD-0332991.html Postoperative nutritional therapy is of paramount importance for patients undergoing esophagectomy. The jejunostomy and nasoenteral tube are the popular routes for nutritional therapy. However, which one is the preferred route is unclear. This study aims to analyze the differences in safety and efficacy of the two routes for nutritional therapy. PubMed, Web of Science, Cochrane Library, and EMBASE (till September 17, 2020) were searched. The primary outcome was postoperative pneumonia. Secondary outcomes were the length of hospital stays (LOS), bowel obstruction, catheter dislocation, anastomotic leakage, overall postoperative complications, and postoperative albumin. Weighted mean differences (WMD) and odds ratios (OR) were calculated for statistical analysis. Ten studies involving a total of 1,531 patients in the jejunostomy group and 1,375 patients in the nasoenteral tube group were included. Compared with patients in the nasoenteral tube group, those in the jejunostomy group had a lower incidence of postoperative pneumonia (OR=0.68, P < 0.001), shorter LOS (WMD=-0.85, P < 0.001), and lower risk of catheter dislocation (OR=0.15, P=0.001). There were no significant differences in the incidence of anastomotic leakage (OR=0.84, P=0.43), overall postoperative complications (OR=0.87, P=0.59), and postoperative albumin (WMD=-0.40, P=0.24). However, patients in the jejunostomy group had a higher risk of bowel obstruction (OR=8.42, P=0.002). Jejunostomy for enteral nutrition showed superior outcomes in terms of postoperative pneumonia, LOS, and catheter dislocation. Jejunostomy may be the preferred enteral nutritional route following esophagectomy. Jejunostomy for enteral nutrition showed superior outcomes in terms of postoperative pneumonia, LOS, and catheter dislocation. Jejunostomy may be the preferred enteral nutritional route following esophagectomy. Conventional models of hypertrophic preconditioning (C-HP) can b

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