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https://www.selleckchem.com/products/ca3.html Narrative Exposure Therapy (NET) is an intervention for trauma-spectrum disorders. Originally developed to treat refugee populations, NET has since been tested for efficacy across different settings. In this review, the NET evidence-base is examined through a retrieval, synthesis, and appraisal of randomised-controlled trials (RCTs) published since 2002. Two independent reviewers (SR & NS) searched online databases including EMBASE, PsycINFO, and PubMed. Twenty-four RCTs were selected for a meta-analysis of three outcomes PTSD diagnosis and PTSD and depression symptoms. All outcomes were analysed at short-term (3 - 4 months), mid-term (6 - 7 months), and long-term (≥ 12 months) data points. A random-effects model was applied to yield standardized mean differences (SMDs) and odds ratios (OR) as indicators of NET treatment effect. Subgroup analyses for type of trauma and type of control groups were conducted to examine potential heterogeneity. For the NET group, moderate effect sizes for PTSD symptom severity were observed at mid- and long-term, and at mid-term for depression symptom severity. The number of PTSD diagnoses decreased significantly in the short-term for the NET condition, but this was not sustained at the long-term. Caution must be exercised when interpreting these results due to high heterogeneity estimates and low quality of evidence across trials. Potential small-study effects further complicate the interpretation of the findings. Recommendations are made for augmenting statistical significance research with qualitative analysis of NET efficacy to better inform clinical practice.Fluoropyrimidine (FP) plus platinum chemotherapy has been recently established as a second-line (L2) preferred option in advanced biliary tract cancer (aBTC) (ABC-06 phase III trial). However, the overall survival (OS) benefit was limited and comparison with FP monotherapy was not available. Our aim was to assess the OS of patients

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