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https://www.selleckchem.com/products/blz945.html Recent studies identified a redistribution of positive mechanical work from distal to proximal joints during prolonged runs, which might partly explain the reduced running economy observed with running-induced fatigue. Higher mechanical demand of plantar flexor muscle-tendon-units, e.g., through minimal footwear, can lead to an earlier onset of fatigue, which might affect the redistribution of lower extremity joint work during prolonged runs. Therefore, the purpose of this study was to examine the effects of a racing-flat and cushioned running shoe on the joint-specific contributions to lower extremity joint work during a prolonged fatiguing run. On different days, eighteen runners performed two 10-km runs with near-maximal effort in a racing-flat and a cushioned shoe on an instrumented treadmill synchronized with a motion-capture-system. Joint kinetics and kinematics were calculated at 13 pre-determined distances throughout the run. The effects of shoes, distance, and their interaction were analyzed usindid not find a difference between shoes in the fatigue-related redistribution of joint work from distal to more proximal joints, more systematical studies are needed to explore the effects of specific footwear design features. Exercise guidelines recommend incorporating resistance exercise (RE) into a regular aerobic training program during pregnancy. Yet, few women do so due to uncertainties about the safety of prenatal RE, particularly regarding the Valsalva maneuver (VM). The aim of this study was to determine the acute cardiovascular responses to prenatal RE at different intensities, with and without VM. Healthy pregnant (n=15; 22.9±5.9 weeks gestation) and non-pregnant women (n=15) were recruited. Maximal strength over 10-repetitions (10RM) for semi-reclined leg press was determined. Women underwent standardized assessments of cardiac structure, function and mechanics (echocardiography), heart rate (ECG) and bloo

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