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https://www.selleckchem.com/products/wnt-agonist-1.html 03, 95% CI=0.84 to 1.25; I =66%; 4 trials). When PtDAs formtats were compared, there were similar effects but no difference between PtDAs (4 trials). There was low to very low GRADE certainty of evidence for the effect of PtDAs on decision quality and quality of the decision-making process compared to usual care. No differences were found when different formats of PtDAs were compared (moderate to very low GRADE certainty of evidence). There was low to very low GRADE certainty of evidence for the effect of PtDAs on decision quality and quality of the decision-making process compared to usual care. No differences were found when different formats of PtDAs were compared (moderate to very low GRADE certainty of evidence).Evidence-Based Medicine (EBM) encourages clinicians to seek the most reputable evidence. The quality of evidence is organized in a hierarchy in which randomized controlled trials (RCTs) are regarded as least biased. However, RCTs are plagued by poor generalizability, impeding the translation of clinical research to practice. Though the presence of poor external validity is known, the factors that contribute to poor generalizability have not been summarized and placed in a framework. We propose a new population-oriented conceptual framework to facilitate consistent and comprehensive evaluation of generalizability, replicability, and assessment of RCT study quality.There is currently a lack of information regarding neuropathic pain in the very early stages of spinal cord injury (SCI). In the present study, neuropathic pain was assessed using the Douleur Neuropathique 4 Questions (DN4) for the patient's worst pain within the first 5 days of injury (i.e., hyperacute) and on follow-up at 3, 6, and 12 months. Within the hyperacute time-frame (i.e., 5 days), at- and below level neuropathic pain were reported as the worst pain in 23% (n=18) and 5% (n=4) of individuals with SCI, respectively. Compared to th

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