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https://www.selleckchem.com/products/aunp-12.html Test whether a martial arts-based therapy, Kids Kicking Cancer (KKC), can reduce pain and emotional distress in children with cancer, other chronic health conditions (e.g., sickle cell), and healthy siblings. This study surveyed children's pain and distress levels immediately before and after a 1-hr in-person KKC class. Eligible participants were enrolled in standard KKC classes, were diagnosed with a chronic health condition (e.g., cancer, sickle cell) or were the sibling of a child diagnosed and were between the ages of 5-17 years (inclusive). Children reported on their pain and distress using Likert-style scales (Coloured Analog Scale and modified FACES scale, respectively). Friedman test was used to test for overall changes in pain and distress, and within subgroups. Age and sex effects were evaluated using Spearman's rank-order correlation. Additional Yes/No questions were administered regarding KKC satisfaction and use of techniques. Fifty-nine youth (19 cancer patients, 17 non-cancer patients, 23sex. Ninety-six percent of youth would recommend KKC to others and 81% reported using KKC techniques (e.g., the Breath Brake or other martial arts techniques) outside of class, such as at home. Results support the more widespread application of KKC as a psychosocial intervention for reducing pain and distress in various pediatric populations. Results support the more widespread application of KKC as a psychosocial intervention for reducing pain and distress in various pediatric populations. Vitamin D contributes to bone health and extra-skeletal effects. The mechanisms underlying vitamin D metabolism have not been extensively evaluated. The relationships between vitamin D and inflammatory cytokines are debated. Our objective was to investigate whether supplemental interferons are associated with longitudinal change of vitamin D status in humans. A total of 48 patients with 24 or 48 weeks of pegylated interferon-α plus

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