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https://www.selleckchem.com/products/fumarate-hydratase-in-1.html We aimed to evaluate the efficacy of the modified Atkins diet in children with epileptic spasms who had failed hormonal therapy. Children aged 9 months to 3 years having daily epileptic spasms despite a trial of ACTH or oral prednisolone and 1 additional anticonvulsant medication were enrolled. Children were randomly assigned to receive the modified Atkins diet either immediately or after a delay of 4 weeks. The ongoing anticonvulsant medications were continued unchanged. The primary outcome variable was the proportion of children who achieved spasm freedom as per parental reports at 4 weeks. Secondary outcomes included time to spasm cessation, proportion of children with electroclinical remission, the proportion of children with >50% reduction of spasms at 4 weeks, and adverse effects of the diet. (ClinicalTrials.gov Identifier NCT03807141). A total of 91 children were enrolled in the study; 46 in the diet group and 45 in the control group. At the end of 4 weeks, 11 children in the diet group were spasm free compared with none in the control group ( ≤ .001). The median time to achieve spasm cessation was 10 days (interquartile range 9-20). Nine of these had resolution of hypsarrhythmia on electroencephalography (EEG). Thirty (65.2%) in the diet group had >50% reduction in spasms, compared with none in the control group ( < .001). The most common side effect was constipation, noted in 34.8% of the children. The modified Atkins diet was found to be effective and well tolerated in children with epileptic spasms refractory to hormonal therapy. The modified Atkins diet was found to be effective and well tolerated in children with epileptic spasms refractory to hormonal therapy.One of the most consistent predictors of fear of crime is gender, whereby women are more fearful of crime than men, despite their lower rates of victimization. An often-cited explanation for this apparent paradox is the "shadow" of

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